Invasive Ductal Breast Cancer; Relationship with Vascular Endothelial Growth Factor and Nitric Oxide

Özdoğan H. K. , Eraldemir F. C. , Çekmen M. B. , Utkan N. Z.

Acta Oncologica Turcica, vol.49, no.2, pp.74-79, 2016 (Peer-Reviewed Journal)

  • Publication Type: Article / Article
  • Volume: 49 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.5505/aot.2016.79188
  • Journal Name: Acta Oncologica Turcica
  • Journal Indexes: TR DİZİN (ULAKBİM)
  • Page Numbers: pp.74-79


INTRODUCTION: Breast cancer is the second leading cause of cancer deaths in western among woman worlwide.Cancer that forms in tissues of the breast usually the ducts or lobules. The aim of the present study was to investigate the association between serum NO and VEGF levels and lymph node status and tumor size of breast carcinoma.
METHODS: In this study we measured serum VEGF and NO levels in 50 patients with breast cancer and 38 healty controls.
RESULTS: Serum VEGF and NO levels are higher patients with breast cancer than controls (p<0.001). İn terms of tumoral size, there is no significant difference serum NO levels in the patients with breast cancer. There are positive correlation between serum NO levels and serum VEGF levels (r: 0.380, p=0,006) in the patients with breast cancer.
DISCUSSION AND CONCLUSION: Serum VEGF and NO levels may be a useful marker to predict prognosis of patients with breast cancer.To clarify this hypothesis, larger studies with long-term follow -up are needed.