May glutathione S-transferase M1 positive genotype afford protection against primary open-angle glaucoma?


YILDIRIM O., ATES N., TAMER L., OZ O., YILMAZ A., ATIK U., ...Daha Fazla

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, cilt.243, ss.327-333, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 243 Konu: 4
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1007/s00417-004-1013-9
  • Dergi Adı: GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
  • Sayfa Sayıları: ss.327-333

Özet

Purpose: To find out whether the polymorphism at GSTM1, GSTT1 and GSTP1 loci is associated with increased susceptibility to glaucoma. Methods: We genotyped 153 primary open angle patients and 159 healthy controls. Genomic DNA from peripheral blood was examined using polymerase chain reaction and defined for the genetic polymorphisms of glutathione S-transferase. Results: The frequency of the GSTM1 null genotype individuals among the glaucoma patients was significanlty higher than in controls (54.9 vs 40.9%) with odds ratio of 1.64 ( 95% CI: 1.10 - 2.59). The frequency of the GSTT1 and GSTP1 in both groups were not statistically different. Conclusion: The present study suggests that the GSTM1 null genotype may be a genetic risk factor for development of primary open angle glaucoma. Further associations studies in other polymorphic genes for xenobiotic - metabolizing enzymes are needed to elucidate the environmental-genetic interaction in the underlying cause of primary open angle glaucoma.