Development of Acute Encephalopathy Due to Vigabatrin Use in a Case of Nonketotic Hyperglycinemia

Karatoprak E. , Saltik S.

EPILEPSI, cilt.18, ss.33-37, 2012 (ESCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 18 Konu: 3
  • Basım Tarihi: 2012
  • Doi Numarası: 10.5505/epilepsi.2012.48403
  • Dergi Adı: EPILEPSI
  • Sayfa Sayıları: ss.33-37


A 3-month-old boy with early myoclonic epilepsy owing to nonketotic hyperglycinemia developed acute encephalopathy after -vigabatrin was presented. Due to the use of vigabatrin, the elevated gamma-aminobutyric acid (GABA) concentration in the brain together with the elevated levels of glycine enhanced the encephalopathy. Our observations indicate the risk of using vigabatrin in patients with nonketotic hyperglycinemia.