Possible antiapoptotic and neuroprotective effects of magnesium sulfate on retina in a preterm hypoxic-ischemic rat model.


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Imamoğlu S., Yalin Imamoğlu E., Erdenöz S., Cumbul A., Uslu Ü., Aktaş Ş., ...More

Turkish journal of medical sciences, vol.51, pp.2198-2205, 2021 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51
  • Publication Date: 2021
  • Doi Number: 10.3906/sag-2012-119
  • Journal Name: Turkish journal of medical sciences
  • Journal Indexes: Science Citation Index Expanded, Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.2198-2205
  • Keywords: Hypoxia-ischemia, magnesium sulfate, neuroprotection, retina, ENDOTHELIAL GROWTH-FACTOR, BRAIN-INJURY, EXPRESSION, RECEPTOR, ACTIVATION, EXPOSURE, NEURONS, PROTECT

Abstract

Background/aim: The effects of systemic magnesium sulfate (MgSO4) on retina in pretenn hypoxic-ischemic (HI) rat model are not known. Our aim was to investigate the effects of MgSO4 on retinal ganglion cell (RGC) count, retinal ganglion cell (RGC) apoptotic index, retinal vascular endothelial growth factor receptor-2 (VEGFR-2), and glial fibrillary acidic protein (GFAP) expressions in preterm HI rat model.