Influence of 4,4,4-Trifluoro-1-phenyl-1,3-butanedione on Selectivity of All-Solid-State Lithium Ion Electrode Prepared by Using 6,6-Dibenzyl-1,4,8-11-tetraoxacyclotetradecane as Ionophore and Its Application in Human Serum Analysis

Yıldırım R., Ağır İ. , Niğde M., Işıldak İ.

International Journal Of Electrochemical Science, vol.15, pp.11468-11478, 2020 (Journal Indexed in SCI Expanded)

  • Publication Type: Article / Article
  • Volume: 15
  • Publication Date: 2020
  • Doi Number: 10.20964/2020.11.30
  • Title of Journal : International Journal Of Electrochemical Science
  • Page Numbers: pp.11468-11478


In this work, we aimed to increase the selectivity of lithium selective electrodes containing lithium ionophore VI in the membrane matrix by using 4, 4, 4-Trifluoro-1-phenyl-1, 3-butanedione (HBTA). Potentiometric response characteristics of the prepared lithium selective electrodes were investigated. Increasing the ratio of HBTA molecule in the membrane cocktail from 0.5% to 1.5% provided a better response with respect to the lower detection limit (LDL), linear range, and selectivity. The LDL and linear range of the electrode with 1.5% HBTA were 7.6× 10-6 mol L-1 and 1.0× 10-1 ̶ 3.4× 10-5 mol L-1 respectively, with a slope 54.3 mV/decade (R2= 0.9998). The potentiometric responses of all electrodes were pH-independent in the range of pH 3-12. The response time of the electrodes was less than 10 s and the lifetime was more than eight weeks. The electrode with 1.5% HBTA showed a better selectivity against sodium (1: 575) and potassium (1: 270) and was successfully applied for the determination of lithium levels in diluted human serum samples. The obtained potentiometric data were compared with the ICP-MS results at 98% confidence level.