Protective effects of chronic melatonin treatment against renal ischemia/reperfusion injury in streptozotocin-induced diabetic rats


Kurçer Z., Parlakpınar H., Vardı N., Taşdemir S., Iraz M., Fadıllıoğlu E., ...Daha Fazla

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, cilt.115, ss.365-371, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 115 Konu: 6
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1055/s-2007-971056
  • Dergi Adı: EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
  • Sayfa Sayıları: ss.365-371

Özet

Aims: The purpose of this study was to investigate the effects of chronic administration of melatonin on renal ischemia/reperfusion (IR) injury in streptozotocin (STZ)-induced diabetic rats.

Aims: The purpose of this study was to investigate the effects of chronic administration of melatonin on renal ischemia/reperfusion (IR) injury in streptozotocin (STZ)-induced diabetic rats. 

Methodology: Male Sprague-Dawley rats were divided into six groups: control (C), diabetes mellitus (DM), control+IR (C+IR), DM+IR, Melatonin+IR (Mel+IR), DM+Mel+IR. Diabetic and non-diabetic rats were given melatonin 4mg/kg/day, i.p., for 15 days. The left renal artery and vein of rats were occluded for 30 min at the 18 th day, followed by 24h of reperfusion. 

Results: In comparison with control group, the levels of malondialdehyde (MDA), protein carbonyl (PC) and and nitric oxide (NO) were determined to be higher in the renal homogenates of DM, DM + IR and C + IR groups. MDA and NO levels were found to be similar in the DM + melatonin + IR and control groups. The most significant histological damage was found in the DM + IR group and this damage was significantly reduced by melatonin. 

Conclusion: Chronic melatonin treatment reduces renal injury by reducing lipid oxidation and NO production in STZ-induced diabetic rats exposed to IR.