Sweet dreams: therapeutic insights, targeting imaging and physiologic evidence linking sleep, melatonin and diabetic nephropathy


AFŞAR B., ELSÜRER AFŞAR R., Sag A. A. , KANBAY A. , KORKMAZ H., Cipolla-Neto J., ...More

CLINICAL KIDNEY JOURNAL, vol.13, no.4, pp.522-530, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 13 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.1093/ckj/sfz198
  • Title of Journal : CLINICAL KIDNEY JOURNAL
  • Page Numbers: pp.522-530

Abstract

Melatonin is the main biochronologic molecular mediator of circadian rhythm and sleep. It is also a powerful antioxidant and has roles in other physiologic pathways. Melatonin deficiency is associated with metabolic derangements including glucose and cholesterol dysregulation, hypertension, disordered sleep and even cancer, likely due to altered immunity. Diabetic nephropathy (DN) is a key microvascular complication of both type 1 and 2 diabetes. DN is the end result of a complex combination of metabolic, haemodynamic, oxidative and inflammatory factors. Interestingly, these same factors have been linked to melatonin deficiency. This report will collate in a clinician-oriented fashion the mechanistic link between melatonin deficiency and factors contributing to DN.