Seismic isolation is generally considered an effective earthquake protection strategy. As application of seismic isolation increases, decisions on the use of one particular isolator versus another isolator increasingly depend on computed responses with complex analytical models. Accordingly, validation of analytical models to predict primary (structural) and secondary system (non-structural component) response in seismically isolated buildings becomes very important. This paper presents comparisons of experimental and analytical results on the primary and secondary system response of a building model in order to provide information on the accuracy of the predicted response. The tested model was configured as a 6-story building at quarter length scale in a momentframe configuration, and with the following seismic isolation systems: a) Low damping elastomeric bearings with and without linear or nonlinear viscous dampers, b) Single Friction Pendulum (FP) bearings with and without linear or nonlinear viscous dampers, and c) Lead-rubber bearings. Response quantities compared include story drifts and isolator shear forces and displacements for the primary system, and peak floor total velocities and floor response spectra that relate to secondary system response. This paper presents samples results out of a total of 288 comparisons of experimental and analytical results presented in an MCEER report. It is shown that the primary and secondary system response is computed with sufficient accuracy by the analytical models but some response quantities may be underestimated or overestimated by significant amounts.