Novel chromosomal translocations in multiple myeloma: t(13;16)(q14;q24) and t(1;15)(q10;q26)


Akalin I. , Kutlay N. Y. , İlhan O., Tükün A.

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, cilt.29, ss.215-220, 2007 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 29 Konu: 3
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1111/j.1365-2257.2006.00837.x
  • Dergi Adı: INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
  • Sayfa Sayıları: ss.215-220

Özet

Multiple myeloma (MM) is a malignant plasma cell disorder that involves multiple genetic abnormalities. Chimeric transcription factors, created by gene fusion as a result of chromosomal translocations, have been implicated in the pathogenesis of the disease. Here, we report the conventional cytogenetic analysis of a MM patient that showed a complex set of novel chromosomal rearrangements, including t(13;16)(q14;q24) and t(1;15)(q10;q26). This is probably the result of fusion of previously known genes, and would contribute to prognostic significance of the disease.