The Effect of Garlic Derivatives (S-Allylmercaptocysteine, Diallyl Disulfide, and S-Allylcysteine) on Gentamicin Induced Ototoxicity: An Experimental Study


UZUN L. , Kokten N., Cam O. H. , KALCIOĞLU M. T. , Ugur M. B. , TEKİN M. , et al.

CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY, cilt.9, ss.309-313, 2016 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 9 Konu: 4
  • Basım Tarihi: 2016
  • Doi Numarası: 10.21053/ceo.2015.01032
  • Dergi Adı: CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
  • Sayfa Sayısı: ss.309-313

Özet

Objectives. Gentamicin is a potent aminoglycoside antibiotic. Ototoxicity and nephrotoxicity are the main side effects which restrict the use of gentamicin. Garlic with its intrinsic antioxidant activity may prove beneficial in prevention from ototoxicity. S-allylmercaptocysteine (SAMC), diallyl disulfide (DD), and S-allylcysteine (SAC) are three active compounds found in garlic. In this study, we investigated the effect of SAMC, DD, and SAC on the ototoxicity induced by gentamicin in rats, by using brainstem evoked response audiometry (BERA).