Targeting epidermal growth factor receptor pathway with irreversible tyrosine kinase inhibitor


Sagir F. , DEMİROĞLU ZERGEROĞLU A.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.44, ss.62-69, 2019 (SCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 44 Konu: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1515/tjb-2017-0276
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Sayfa Sayısı: ss.62-69

Özet

Background: Malignant mesothelioma (MM) is an endemic disease around central Anatolia region in Turkey, where people are exposed to erionite- and asbestos-contaminated soil. Aberrant EGFR signalling has implicated in several cancers including MMs. Tyrosine kinase inhibitors are new treatment options harbouring deregulated signalling network components. In this study, we aimed to investigate anti-proliferative effect of CL-387,785 in MM cells.