The blockade of the renin-angiotensin system reverses tacrolimus related cardiovascular toxicity at the histopathological level

Agirbasli M. A. , Papila-Topal N., Ogutmen B., Deniz H., Cakalagaoglu F., Tuglular S., et al.

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, cilt.8, ss.54-58, 2007 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 8 Konu: 2
  • Basım Tarihi: 2007
  • Doi Numarası: 10.3317/jraas.2007.009
  • Dergi Adı: JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
  • Sayfa Sayısı: ss.54-58

Özet

Introduction. In this study, we investigate the toxic effects of tacrolimus (FK506) on the cardiovascular system at the histopathological level in a rat model and whether these effects can be reversed by the blockade of the renin-angiotensin system (RAS) by either an angiotensin-converting enzyme inhibitor (ACE-inhibitors) or an angiotensin receptor antagonist (ARB).