The blockade of the renin-angiotensin system reverses tacrolimus related cardiovascular toxicity at the histopathological level


Agirbasli M. A. , Papila-Topal N., Ogutmen B., Deniz H., Cakalagaoglu F., Tuglular S., ...More

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, vol.8, no.2, pp.54-58, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 2
  • Publication Date: 2007
  • Doi Number: 10.3317/jraas.2007.009
  • Title of Journal : JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
  • Page Numbers: pp.54-58

Abstract

Introduction. In this study, we investigate the toxic effects of tacrolimus (FK506) on the cardiovascular system at the histopathological level in a rat model and whether these effects can be reversed by the blockade of the renin-angiotensin system (RAS) by either an angiotensin-converting enzyme inhibitor (ACE-inhibitors) or an angiotensin receptor antagonist (ARB).