The blockade of the renin-angiotensin system reverses tacrolimus related cardiovascular toxicity at the histopathological level

Agirbasli, MEHMET; Papila-Topal, Nurdan; Ogutmen, Betul; Deniz, Hicran; Cakalagaoglu, Fulya; Tuglular, Serhan; Akoglu, Emel

doi:10.3317/jraas.2007.009

The blockade of the renin-angiotensin system reverses tacrolimus related cardiovascular toxicity at the histopathological level

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Agirbasli M. A. , Papila-Topal N., Ogutmen B., Deniz H., Cakalagaoglu F., Tuglular S., ...More

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, vol.8, no.2, pp.54-58, 2007 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 8 Issue: 2
Publication Date: 2007
Doi Number: 10.3317/jraas.2007.009
Title of Journal : JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
Page Numbers: pp.54-58

Abstract

Introduction. In this study, we investigate the toxic effects of tacrolimus (FK506) on the cardiovascular system at the histopathological level in a rat model and whether these effects can be reversed by the blockade of the renin-angiotensin system (RAS) by either an angiotensin-converting enzyme inhibitor (ACE-inhibitors) or an angiotensin receptor antagonist (ARB).