© 2021, Duzce University Medical School. All rights reserved.Aim: Periosteal chondroma is a rare chondroma that is difficult to differentiate. Its localization is similar to other surface periosteal lesions. These lesions have a wide distribution of age. Curettage, marginal excision, or en bloc resection are applied in the surgical treatment. En bloc resection is preferred to reduce recurrence. In this study, we aimed to share the experience of two orthopedic oncology centers in the differential diagnosis and treatment of periosteal chondroma. Material and Methods: Data from two clinics were analyzed retrospectively. Data were collected on demographic data (age, gender), clinical findings (pain, swelling, pressure-related symptom, duration of follow-up), radiological findings (size, bony invasion), pathology results (biopsy, excision), and postoperative complications (recurrence). Results: Fourteen patients were included in the study. En bloc resection was performed in all cases. The mean age of the patients was 31.5±16.5 (range, 8-58) years. 10 (71.4%) patients were male. The mean duration of symptoms was 6.6±4.8 (range, 0-18) months, and the mean follow-up was 46.7±39.6 (range, 6-132) months. Nine (64.3%) patients had pain. Six (42.9%) patients had swelling. One patient (7.1%) had a palpable mass. There was no complaint in 1 (7.1%) patient. One (7.1%) patient underwent biopsy. During the follow-up, no recurrence or complication was observed after en bloc resection. Conclusion: Imaging and histopathological findings of benign and malignant periosteal chondroid tumors may overlap, and accurate differential diagnosis is crucial in the treatment of these lesions. En bloc resection prevents recurrence during follow-up.