Coronary Microvascular function, Peripheral Endothelial Function and Carotid IMT in beta-thalassemia minor


Gullu H., ÇALIŞKAN M., Caliskan Z., Kanat Unler G., Ermisler E., Ciftci O., ...More

THROMBOSIS RESEARCH, vol.131, no.6, 2013 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 131 Issue: 6
  • Publication Date: 2013
  • Doi Number: 10.1016/j.thromres.2013.03.013
  • Journal Name: THROMBOSIS RESEARCH
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Keywords: Thalassemia minor, Coronary flow reserve, Endothelial function, INTIMA-MEDIA THICKNESS, SLOW FLOW PHENOMENON, MYOCARDIAL-INFARCTION, OXIDATIVE STRESS, ARTERY-DISEASE, DOPPLER-ECHOCARDIOGRAPHY, CARDIOVASCULAR-DISEASE, ATHEROSCLEROSIS, RESERVE, TRAIT

Abstract

Higher prevalence of cardiovascular disease in Thalassemia patients have been known. Potential mechanisms are enhanced platelet activation, LDL oxidation, macrophage activation, and increased nitric oxide destruction. We have investigated coronary flow reserve (CFR), brachial artery flow mediated dilation (FMD) and Carotid intima-media thickness (IMT) in patients with Beta thalessemia minor (BTM).