Background: Plant life is extremely diverse, with a great deal of geographic and seasonal variation. Consequently, the range of reported adverse reactions is large, and there are important differences worldwide in the incidence and prevalence of these reactions. Systemic ingestion of some plants containing furocoumarins can cause erythema, edema, vesicle and bulla formation and later hyperpigmentation, after exposure to sunlight. They may at times exhibit clinical manifestations that mimic angioedema, and rarely progress to necrosis. This condition is named phyto-phototoxic reaction.
Ozkol HU, Calka O, Akdeniz N, Pinar SM. Phytodermatitis in eastern Turkey: a retrospective, observational study. Dermatitis. 2014 May-Jun;25(3):140-6. SCI-Expanded 1500