Turkiye Klinikleri Journal of Medical Sciences, vol.39, no.1, pp.48-55, 2019 (Peer-Reviewed Journal)
© 2019 by Türkiye Klinikleri.Objective: To investigate the effect of lymphangitis carcinomatosa on the stage, and survival in the primary lung cancers. Material and Methods: Patients diagnosed with primary lung cancer between 2014-2016 were included in the study. The patients were divided into two groups who were radiologically detected as having lymphangitis carcinomatosa, and who were detected with no lymphangitis carcinomatosa at diagnosis. The demographic, clinical, radiologic, and survival data of the patients were recorded in both groups. The data of both grups were compared. The data of the groups were evaluated using the Chi-square and Mann-Whitney U test and p<0.05 was considered as significant. Results: A total of 319 patients were included in the study. 264 (82.2%) of the cases were male and 55 (17.8%) were female. The mean age of the patients was 61.9±9.6. The average smoking history was 39.1±17.3 pack-years. 28 patients (8.8%) were diagnosed with LC, and 291 (91.2%) were not detected LC. When tumor histopathology of the cases were examined, the most common tumor type squamous cell carcinoma was found in both groups. No difference was detected in the characteristics of the patients diagnosed with LC, and of the patients diagnosed with no LC (Histopathologic diagnosis, stage, surgical/oncologic treatment features, history of smoking, age, and sex). The median general survival times in lung cancers detected with LC (11 months) were very similar particularly with the stage 3B (12 months) cancers with no LC (p=0.524). Conclusion: Lymphangitis carcinomatosa which is known to poorly affect the survival and prognosis, affects the survival in lung cancers. Therefore, LC must be considered in the staging of lung cancer.