Lowering Uric Acid With Allopurinol Improves Insulin Resistance and Systemic Inflammation in Asymptomatic Hyperuricemia

TAKIR, Mumtaz; KOSTEK, Osman; OZKOK, Abdullah; ELCIOGLU, Omer; BAKAN, Ali; Erek, Aybala; MUTLU, HASAN; TELCI, Ozge; SEMERCI, Aysun; ODABAŞ, ALİ; AFSAR, Baris; SMITS, Gerard; ALANASPA, Miguel; SHARMA, Shailendra; JOHNSON, Richard; Kanbay, Mehmet

doi:10.1097/jim.0000000000000242

Lowering Uric Acid With Allopurinol Improves Insulin Resistance and Systemic Inflammation in Asymptomatic Hyperuricemia

TAKIR M., KOSTEK O., OZKOK A., ELCIOGLU O. C. , BAKAN A., Erek A., ...More

JOURNAL OF INVESTIGATIVE MEDICINE, vol.63, no.8, pp.924-929, 2015 (Peer-Reviewed Journal)

Publication Type: Article / Article
Volume: 63 Issue: 8
Publication Date: 2015
Doi Number: 10.1097/jim.0000000000000242
Journal Name: JOURNAL OF INVESTIGATIVE MEDICINE
Journal Indexes: Science Citation Index Expanded, Scopus
Page Numbers: pp.924-929

Abstract

Background Hyperuricemia is an independent predictor of impaired fasting glucose and type 2 diabetes, but whether it has a causal role in insulin resistance remains controversial. Here we tested the hypothesis that lowering uric acid in hyperuricemic nondiabetic subjects might improve insulin resistance.