Outcomes of Gleason score 3+4=7 prostate cancer with minimal amounts (<6%) vs >= 6% of Gleason pattern 4 tissue in needle biopsy specimens

Kir G., Seneldir H., Gumus E.

ANNALS OF DIAGNOSTIC PATHOLOGY, vol.20, pp.48-51, 2016 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20
  • Publication Date: 2016
  • Doi Number: 10.1016/j.anndiagpath.2015.10.013
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.48-51
  • Keywords: Prostate cancer, Gleason pattern 4, Biopsy, Radical prostatectomy, Modified Gleason grading, 2005 INTERNATIONAL-SOCIETY, PATHOLOGY ISUP CONSENSUS, RADICAL PROSTATECTOMY, GRADING SYSTEM, CARCINOMA, IMPACT, DISEASE


Objective: The International Society of Urological Pathology Gleason grading system was modified in 2005. Since the modified system was introduced, many cancers that previously would have been categorized as Gleason score (GS) 6 are now categorized as GS 7 based on biopsy specimens that only contain minimal amounts (<6%) of Gleason pattern (GP) 4 tissue. However, the clinical significance of observing <6% of GP 4 tissue in biopsies of GS 7 prostate cancer has not been studied.