Assessment of Mean Platelet Volume in Patients with AA Amyloidosis and AA Amyloidosis Secondary to Familial Mediterranean Fever: A Retrospective Chart - Review Study

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Bakan A., Oral A., ALIŞIR ECDER S., Kuzgun G. S. , Elcioglu O. C. , Demirci R., ...More

MEDICAL SCIENCE MONITOR, vol.25, pp.3854-3859, 2019 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 25
  • Publication Date: 2019
  • Doi Number: 10.12659/msm.914343
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.3854-3859


Background: Amyloidosis is a protein-misfolding disease characterized by the deposition of aggregated proteins in the form of abnormal fibrils that disrupt tissue structure, ultimately causing disease. Amyloidosis is very frequent in untreated familial Mediterranean fever (FMF) patients and it is the most important feature that determines the prognosis of FMF disease. The mean platelet volume (MPV) in FMF has been previously studied. However, whether MPV level in FMF patients is lower or higher compared to healthy controls remains a topic of ongoing debate. In this study, we aimed to investigate MPV values and to assess the correlation between MPV and proteinuria in patients with AA amyloidosis and AA amyloidosis secondary to familial Mediterranean fever (AA-FMF) through a retrospective chart-review.