Central nervous system infections in the absence of cerebrospinal fluid pleocytosis


ERDEM H., OZTURK-ENGIN D., Cag Y., SENBAYRAK S., INAN A., Kazak E., ...More

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, vol.65, pp.107-109, 2017 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 65
  • Publication Date: 2017
  • Doi Number: 10.1016/j.ijid.2017.10.011
  • Journal Name: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.107-109
  • Keywords: CSF, Pleocytosis, Leukocyte, Meningitis, Encephalitis, MENINGITIS, DIAGNOSIS, OUTCOMES

Abstract

Previous multicenter/multinational studies were evaluated to determine the frequency of the absence of cerebrospinal fluid pleocytosis in patients with central nervous system infections, as well as the clinical impact of this condition. It was found that 18% of neurosyphilis, 7.9% of herpetic meningoencephalitis, 3% of tuberculous meningitis, 1.7% of Brucella meningitis, and 0.2% of pneumococcal meningitis cases did not display cerebrospinal fluid pleocytosis. Most patients were not immunosuppressed. Patients without pleocytosis had a high rate of unfavorable outcomes and thus this condition should not be underestimated. (C) 2017 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.