The clinical impact of androgen deprivation therapy on SARS-CoV-2 infection rates and disease severity

Kazan O., ÇULPAN M. , Efilog O., Atis G., YILDIRIM A.

TURKISH JOURNAL OF UROLOGY, vol.47, no.6, pp.495-501, 2021 (Journal Indexed in ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 6
  • Publication Date: 2021
  • Doi Number: 10.5152/tud.2021.21278
  • Title of Journal : TURKISH JOURNAL OF UROLOGY
  • Page Numbers: pp.495-501
  • Keywords: Androgen deprivation therapy, prostate cancer, SARS-CoV-2, TMPRSS-2, PROSTATE-CANCER, COVID-19, TMPRSS2, RISK

Abstract

Objective: The protective effect of androgen deprivation therapy (ADT) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel hypothesis. ADT may protect patients with prostate cancer through the inhibition of androgen receptor-dependent transmembrane serine protease type 2. We analyzed the role of ADT on SARS-CoV-2 infection risk and disease severity.