Warfarin-Induced Skin Necrosis Due to Protein C Deficiency in a Dialysis Patient

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Ozkok A., Ozportakal H., Asik M., Ozkok S., Alkan O., Boyraz M., ...More

TURKISH NEPHROLOGY DIALYSIS AND TRANSPLANTATION JOURNAL, vol.27, no.2, pp.214-217, 2018 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.5262/tndt.2018.2775
  • Journal Name: TURKISH NEPHROLOGY DIALYSIS AND TRANSPLANTATION JOURNAL
  • Journal Indexes: Emerging Sources Citation Index, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.214-217

Abstract

Protein-C (PC) is a vitamin-K-dependent anticoagulant proenzyme produced by the liver. PC deficiency may cause both venous and arterial thromboses. In patients with PC deficiency, warfarin further decreases PC activity and causes thrombosis of skin arterioles leading to skin necrosis.