Expression and prognostic significance of cox-2 and p-53 in hodgkin lymphomas: a retrospective study


BARISIK N. O. , BOZKURT S., Gumus M. , Kaygusuz I., KARADAYI N., Bas E., ...More

DIAGNOSTIC PATHOLOGY, vol.5, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 5
  • Publication Date: 2010
  • Doi Number: 10.1186/1746-1596-5-19
  • Title of Journal : DIAGNOSTIC PATHOLOGY

Abstract

Background: Cyclooxygenase (cox) is the rate-limiting enzyme, which catalyzes the conversion of arachidonic acid into prostaglandins and contributes to the inflammatory process. Cyclooxygenase-2 (cox-2), which is one of the two isoforms, plays a role in tumor progression and carcinogenesis. p53 contributes to apoptosis, DNA renewal and cell cycle. Studies concerning the relationship of cox-2 and p53 expressions and carcinogenesis are available, but the association between cox-2 and p53 in Hodgkin lymphoma (HL) is not exactly known. In our study, we examined the association of cox-2 and p53 expression, with age, stage, histopathological subtype, and survival in HL. We also examined correlation between cox-2 and p53 expression.