The effect of photobiomodulation on total amount of substance P in gingival crevicular fluid: placebo-controlled randomized clinical trial.

Yildiz E. D. , Arslan H., Koseoglu S., ARABACI T., Yildiz D. A. , Savran L.

Lasers in medical science, vol.34, no.3, pp.517-523, 2019 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 3
  • Publication Date: 2019
  • Doi Number: 10.1007/s10103-018-2625-3
  • Journal Name: Lasers in medical science
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.517-523
  • Keywords: Substance P, Photobiomodulation, Postoperative pain, Gingival crevicular fluid, LEVEL LASER THERAPY, GENE-RELATED PEPTIDE, SKIN, PAIN, NEUROPEPTIDES, IRRADIATION, MODULATION, MECHANISMS, EXTRACTION


To investigate the effect of photobiomodulation (PBM) and placebo on total amount of substance P in gingival crevicular fluid (GCF) pre- and postoperatively. Twenty-six patients having tooth with symptomatic apical periodontitis were enrolled in this study. GCF was collected preoperatively. The patients were assigned into two groups (n=13), as follows: placebo and PBM. Sampling was repeated 7days after root canal treatment. Two independent samples T test was used for analyzing of the differences between preoperative and postoperative substance P levels in GCF (p=.05). The Pearson correlation analysis was used for determination of correlation among substance P levels and other variables. For placebo group, there is no significant difference between preoperative and postoperative total amounts of substance P level (p=0.553). For PBM group, postoperative total amount of substance P level was significantly higher than those of preoperative level (p=0.005). Within the limitation of the present study, PBM has immunomodulation effect linked to the modulation of the total amount of substance P in the gingival crevicular fluid. Thai Clinical Trials Registry: TCTR20161228002