The neuroprotective effect of lamotrigine against glutamate excitotoxicity in SH-SY5Y human neuroblastoma cells


TERZİOĞLU BEBİTOĞLU B. , OĞUZ E., Acet N. G. , Hodzic A., Temel F., ADA S. , ...More

MARMARA MEDICAL JOURNAL, vol.33, no.3, pp.146-152, 2020 (Journal Indexed in ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 3
  • Publication Date: 2020
  • Doi Number: 10.5472/marumj.816319
  • Title of Journal : MARMARA MEDICAL JOURNAL
  • Page Numbers: pp.146-152
  • Keywords: Lamotrigine, Glutamate excitotoxicity, SH-SY5Y, Oxidative stress parameter, Cytokines, MK-801, OXIDATIVE STRESS, HYDROGEN-PEROXIDE, CALCIUM, INJURY, MODEL

Abstract

Objective: Glutamate-induced excitotoxicity has a role in the pathophysiology of neurodegenerative disorders. Lamotrigine, an antiepileptic drug, also used to treat bipolar disorders, may be protective against excitotoxic insult. The aim of the study was to investigate the neuroprotective effect of lamotrigine against the glutamate excitotoxicity in SH-SY5Y cell line.