MARMARA MEDICAL JOURNAL, vol.33, no.3, pp.146-152, 2020 (Peer-Reviewed Journal)
Article / Article
MARMARA MEDICAL JOURNAL
Emerging Sources Citation Index, Scopus, Academic Search Premier, CINAHL, EMBASE, TR DİZİN (ULAKBİM)
Lamotrigine, Glutamate excitotoxicity, SH-SY5Y, Oxidative stress parameter, Cytokines, MK-801, OXIDATIVE STRESS, HYDROGEN-PEROXIDE, CALCIUM, INJURY, MODEL
Objective: Glutamate-induced excitotoxicity has a role in the pathophysiology of neurodegenerative disorders. Lamotrigine, an antiepileptic drug, also used to treat bipolar disorders, may be protective against excitotoxic insult. The aim of the study was to investigate the neuroprotective effect of lamotrigine against the glutamate excitotoxicity in SH-SY5Y cell line.