MARMARA MEDICAL JOURNAL, vol.33, no.3, pp.146-152, 2020 (Journal Indexed in ESCI)
Article / Article
Title of Journal :
MARMARA MEDICAL JOURNAL
Lamotrigine, Glutamate excitotoxicity, SH-SY5Y, Oxidative stress parameter, Cytokines, MK-801, OXIDATIVE STRESS, HYDROGEN-PEROXIDE, CALCIUM, INJURY, MODEL
Objective: Glutamate-induced excitotoxicity has a role in the pathophysiology of neurodegenerative disorders. Lamotrigine, an antiepileptic drug, also used to treat bipolar disorders, may be protective against excitotoxic insult. The aim of the study was to investigate the neuroprotective effect of lamotrigine against the glutamate excitotoxicity in SH-SY5Y cell line.