Intestinal blood flow by Doppler ultrasound: the impact of clarithromycin treatment for feeding intolerance in preterm neonates

SANCAK S., ARMAN D., GURSOY T., TOPCUOGLU S., KARATEKIN G., Ovali F.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, vol.29, no.11, pp.1853-1856, 2016 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 11
  • Publication Date: 2016
  • Doi Number: 10.3109/14767058.2015.1066327
  • Journal Name: JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.1853-1856

Abstract

Objective: To compare the blood flow velocities of superior mesenteric artery (SMA) before versus after clarithromycin treatment for feeding intolerance in very low-birth weight infants.Methods: A prospective study was conducted in a group of infant <1500g with feeding intolerance who received clarithromycin 7.5mg/kg/dose bid. Before and at the third day of the clarithromycin therapy, SMA blood flow velocity was measured with Doppler ultrasound.Results: SMA peak systolic velocity (PSV) and mean systolic velocity (MV) on the third day of the treatment was found significantly higher than the initial measurement (p=0.013 and p=0.027, respectively). End diastolic velocity of the SMA did not change with clarithromycin therapy (p=0.113). There were no significant changes about pulsatility and resistive index of SMA with regard to clarithromycin therapy.Conclusion: Clarithromycin effects the splanchnic circulation. The rise in PSV and MV in SMA is remarkable. These results suggest that the splanchnic blood flow increases significantly after clarithromycin usage.