Protective effects of long-term probiotic mixture supplementation against pentylenetetrazole-induced seizures, inflammation and oxidative stress in rats.

Kilinc E., Ankarali S., Ayhan D., Ankarali H., Torun I. E. , Cetinkaya A.

The Journal of nutritional biochemistry, vol.98, 2021 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 98
  • Publication Date: 2021
  • Doi Number: 10.1016/j.jnutbio.2021.108830
  • Journal Name: The Journal of nutritional biochemistry
  • Journal Indexes: Science Citation Index Expanded, Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, CINAHL, EMBASE, Environment Index, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Keywords: Epilepsy, Microbiota, (neuro)inflammation, Oxidative stress, Probiotic, GUT MICROBIOTA, EPILEPSY, BRAIN, NEUROINFLAMMATION, CHILDREN, INFANTS, DISEASE, MOUSE


Emerging evidence indicates that dysbiosis of gut microbiota plays an important role in epilepsy, although the underlying mechanisms remain unclear due to the complex nature of both microbial composition and pathophysiology of epilepsy. We investigated effects of long-term probiotics supplementation on epileptic seizures, and inflammatory and oxidant/antioxidant biomarkers in a pentylenetetrazole(PTZ)-induced seizure model in rats.