Enhanced mRNA expression of plasminogen activator inhibitor-1 in livedoid vasculopathy lesions

Agirbasli, MEHMET; Goktay, Fatih; Peker, Irem; Gunes, Pembegul; Aker, Fugen; AKKİPRİK, MUSTAFA

doi:10.1111/1755-5922.12255

Enhanced mRNA expression of plasminogen activator inhibitor-1 in livedoid vasculopathy lesions

Agirbasli M. A. , Goktay F., Peker I., Gunes P., Aker F. V. , AKKİPRİK M.

CARDIOVASCULAR THERAPEUTICS, vol.35, no.3, 2017 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 35 Issue: 3
Publication Date: 2017
Doi Number: 10.1111/1755-5922.12255
Title of Journal : CARDIOVASCULAR THERAPEUTICS
Keywords: Fibrinolysis, Plasminogen activator inhibitor 1, Plasminogen inactivators, Thrombosis, Topical administration, Vascular diseases, VASCULITIS, DISEASE, PAI-1, POPULATION, MUTATION, LEIDEN

Abstract

AimThrombosis and inflammation play an important role in pathophysiology of livedoid vasculopathy (LV). Plasminogen activator inhibitor-1 (PAI-1) is the main physiological inhibitor of fibrinolysis and is a pivotal modulator in a broad range of biological processes.